Dev Engineer

Job Posting

 

We have a current opening for the following position. If you are interesting in being considered for this position, please contact Denise Kilpatrick or Andrew Graham.

 

Position:  Development Engineer I

Reporting to: Senior Development Engineer

Division: Process Development

Date: November 19th, 2008

 

Basic Functions:

 

Design, conduct, and analyze experiments in support of process development activities aimed to implement, optimize, or scale-up the manufacture of viral vector vaccines.

 

Principal Accountabilities:

 

1. Evaluate and develop methodologies for viral replicon particles (VRP) purification including, but not limited to filtration and chromatography processes.
2. Design, test, and implement strategies for aseptic cell harvesting, washing and concentration.
3. Optimize and implement electroporation techniques and equipment for cell transfection.
4. Develop VRP harvest protocols using filtration.
5. Support scale-up activities.
6. Collaborate in the production of VRP in support of development activities.
7. Support pilot lot and manufacturing activities as well as the transfer of large scale processes into manufacturing.
8. Contribute to process qualification and validation.

 

 

QUALIFICATIONS:

• BS in Chemical Engineering, Biochemical Engineering, or related field.
• BS+4 or MS+2 years of related industrial cGMP manufacturing or research development experience.
• An understanding of the basics of molecular biology, tissue culture, and purification methods is essential.
• Process validation and scale-up experience necessary.
• A thorough understanding of a cGMP environment is essential.
• The ideal candidate will have filtration and fluid mechanics experience in a vaccine or protein environment as well as a thorough understanding of biopharmaceutical purification processes.
• Experience with cell culture techniques, bioreactor operation, cell harvesting, and centrifugation systems is desirable.
• The candidate must have a thorough understanding of aseptic techniques and CIP/SIP operations.
• Basic understanding of statistics and experimental design is a plus.
• Good documentation practices and communication skills are of the outmost importance.