Metabolon Seminar FLYER

BTEC
Seminar

Metabolic
Profiling for Optimization of the Microbial and Mammalian Systems
Used in Biologics Production

Kirk Beebe, PhD

Scientific
Project Leader

Metabolon,
Inc.

800
Capitola Dr. Suite 1

Durham,
NC 27713, USA

Abstract:

Unbiased
global metabolic profiling is an approach for obtaining insight into
the metabolism of a population of cells in a culture environment. As
such, it has had particular utility in the area of upstream
bioprocess optimization of biopharmaceuticals. The hundreds of
metabolites detected by global profiling offer a vastly expanded
panel of biochemicals for monitoring media formulations for
unexpected nutrient depletion or toxicant accumulation. Further,
this panel has yielded detailed insight into why such metabolites
diminish or accumulate. Finally, metabolites that directly impact key
areas of phenotypic output such as stability of the transgene,
glycosylation, and cell viability are often identified by distinct
media formulations by metabolomics.

Speaker
Bio:

Kirk
received his Ph.D. in biochemistry from Ohio State University.
Following this, he was a postodoctoral scientist and senior research
associate at the Scripps Research Institute where he uncovered
connections between protein translational fidelity and
neurodegenerative diseases. He began his career as a purification
process development scientist at Talecris Biotherapeutics where he
gained an appreciation for the challenges of upstream process
development.

When:
Friday, May 1, 2009

Where:
119 BTEC (850 Oval Drive – Centennial Campus)

Time: 1:00
– 2:00P